How Should We Manage Iatrogenic Perforation Caused by Colonoscopy?

Colonoscopy is widely performed in Korea for screening, diagnostic, and therapeutic purposes. However, serious complications of colonoscopy, such as iatrogenic colon perforation, have been reported. The rate of perforation in colonoscopy is 0.1% to 0.3%. Perforation occurs in 0.19% to 0.29% of colon polypectomies, and the risk increases to 1.9% in elderly patients. Colon perforation is associated with high morbidity and mortality, and adequate management and decision-making strategy is necessary. How should we manage iatrogenic perforation caused by colonoscopy? Decision-making is important because of the associated unsatisfactory clinical course, prolonged hospital day, increased cost, malpractice claims, and patient dissatisfaction. In this issue of Clinical Endoscopy, Shin et al. reported the clinical outcomes of several management strategies for iatrogenic colonoscopic perforations. Twenty of 41 patients underwent conservative management, with a success rate of 90%. Two patients were converted to surgical management after the failure of initial conservative management. Surgical management was performed in 23 patients, including two who failed conservative management. Of 14 patients who underwent surgery at 8 hours after the perforation, there was no significant difference in adverse outcomes between the laparotomy group and the laparoscopic surgery group. The medical costs and claim rate were 1.45 and 1.87 times greater in the exploratory laparotomy group, respectively. Shin et al. concluded that conservative management of colonoscopic perforation could be an option for patients without overt symptoms of peritonitis or with a small defect size. If surgical management is required, laparoscopic surgery may be considered as the initial procedure even with a delayed diagnosis. In this study, the number of enrolled patients was relatively small, and the data were collected retrospectively; therefore, prospectively randomized controlled data are needed to establish management strategies with strong evidence. Despite this limitation, we have several management option for iatrogenic colon perforation. First, we can use endoscopic closure with a clip device in limited situations. The perforation must be found immediately after colonoscopy, the bowel preparation should be clean, the perforation should be smaller than 10 mm, and the patient’s condition should be good, with no evidence of peritonitis. Of course, endoscopic clipping should be performed by experienced endoscopists. For a more effective and comfortable procedure, CO2 insufflation is recommended. An overthe-scope device is also recommended for effective closure of perforations at a center with this availability. Second, laparoscopic surgery can be a choice for manageReceived: May 7, 2016 Revised: May 20, 2016 Accepted: May 23, 2016 Correspondence: Eun Sun Kim Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea Tel: +82-2-920-6555, Fax: +82-2-923-1943, E-mail: [email protected]